"The Secret Behind the Science"
Standard classification terms for olfactory disorders are anosmia (absence of smell), hyposmia (diminished sensitivity of smell), and dysosmia (distortion of normal smell).
Olfactory disorders -HYPOSMIA, ANOSMIA, DYSOSMIA, are the most prominent early indicators of many underlying disorders.
Neurological-Neurodegenerative disease and Olfactory Disorders.
In the 1970s, researchers learned that smell is compromised in neurodegenerative conditions like Alzheimer's disease , Parkinson's disease , Huntington's disease , and multiple sclerosis (MS). Now, they are discovering that loss of smell can be a hallmark symptom in the earliest stages of many diseases.
"Recent studies of brains from Alzheimer's and Parkinson's disease patients reveal structural and biochemical alterations in regions associated with the sense of smell," says Richard Doty, Ph.D., professor and director of the Smell & Taste Center at the University of Pennsylvania. Loss of smell occurs 90 percent of the time in Parkinson's disease. This is greater than the prevalence of tremor, a cardinal sign of the disorder.
Yet in one study of Parkinson's patients, 72 percent were unaware they had a smell disorder before undergoing standardized testing. Only two out of 34 Alzheimer's disease patients reported suffering from smell and/or taste problems-even though 90 percent of the patients scored lower on standardized smell tests than healthy subjects.
Is Your Sniffer Up to Snuff?
Odors enter the nasal cavity and travel a set of cells at the roof of the nose called the olfactory receptor. When an aroma reaches the receptor, it sends a signal to the brain that says, "Oh, that's vanilla," or "Bacon!!" If the receptors are blocked or dead due to aging or certain medical conditions, the smell won't be perceived.
How do you know if your system is functioning appropriately? Ask your doctor for a sniff test. Most neurologists don't test olfactory function or ask patients about their sense of smell, says Dr. Doty.
Olfactory dysfunction in AD has been reported as early as 1974.4 After 40 years of research, olfactory dysfunction in AD was better understood. Some studies confirmed that olfactory dysfunction was possibly one of the earliest clinical symptoms of AD.5,6 In addition, typical AD pathology first involves the entorhinal cortex. The disease then gradually spreads to the whole brain and eventually affects the entire cerebral cortex.7 Combining olfactory function tests with conventional diagnostic methods could help improve the sensitivity and specificity of AD diagnosis, thereby facilitating early recognition and diagnosis of AD.8 This review article summarizes and evaluates the research progress of olfactory dysfunction in AD to explore further its possible research directions in the future.
SYMPTOMS of COVID-19 infection that occur before you have noticeable symptoms. Viruses inter your body by attaching to cells that are used to identify smells. Our multi-odorant 5-point scent card screens for a full range of hidden olfactory dysfunction and detects these changes.
Olfactory Disorder & COVID-19